Resin effects in solid phase SNAr and SN2 macrocyclizations

被引：0

作者：

Feng, YB ^{[1
]}

Burgess, K ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 2000年 / 71卷 / 01期

关键词：

macrocyclizations; SNAr; resin effects; beta-turn mimics;

D O I：

10.1002/(SICI)1097-0290(200024)71:1<3::AID-BIT2>3.0.CO;2-K

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Seven different supports were compared in solid-phase SNAr and S(N)2 macrocyclization reactions. Product purities were assayed for a relatively facile ring-closure process to give products 1 and 3. Some less-facile ring-closure reactions give the undesired dimeric macrocyclization by-products 2; some of these more-demanding ring closures were also examined. Finally, experiments were performed to gauge the rate of cyclizations on different resins, and some qualitative data were obtained for this. (C) 2000 John Wiley & Sons, Inc.

引用

页码：3 / 8

页数：6

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