HemaSpot, a Novel Blood Storage Device for HIV-1 Drug Resistance Testing

被引：15
|
作者：
Brooks, K. [1 ]
DeLong, A. [2 ]
Balamane, M. [1 ]
Schreier, L. [1 ]
Orido, M. [3 ]
Chepkenja, M. [3 ]
Kemboi, E. [3 ]
D'Antuono, M. [1 ]
Chan, P. A. [1 ]
Emonyi, W. [3 ,4 ]
Diero, L. [3 ,4 ]
Coetzer, M. [1 ]
Kantor, R. [1 ]
机构：
[1] Brown Univ, Div Infect Dis, Alpert Med Sch, Providence, RI 02912 USA
[2] Brown Univ, Ctr Stat Sci, Sch Publ Hlth, Providence, RI 02912 USA
[3] Acad Model Providing Access Healthcare AMPATH, Eldoret, Kenya
[4] Moi Univ, Dept Med, Sch Med, Coll Hlth Sci, Eldoret, Kenya
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2016年 / 54卷 / 01期
关键词：
ANTIRETROVIRAL THERAPY; VIRAL LOAD; SPOT SPECIMENS; SURVEILLANCE; SETTINGS;
D O I：
10.1128/JCM.02853-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
HemaSpot, a novel dried-blood storage filter device, was used for HIV-1 pol resistance testing in 30 fresh United States blood samples and 54 previously frozen Kenyan blood samples. Genotyping succeeded in 79% and 58% of samples, respectively, improved with shorter storage and higher viral load, and had good (86%) resistance mutation concordance to plasma.
引用
收藏
页码：223 / 225
页数：3
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