PROGINS Alu insertion and human genomic diversity

被引:42
|
作者
Donaldson, CJ
Crapanzano, JP
Watson, JC
Levine, EA
Batzer, MA
机构
[1] Louisiana State Univ, Hlth Sci Ctr, Dept Pathol, New Orleans, LA 70112 USA
[2] Louisiana State Univ, Hlth Sci Ctr, Dept Genet, New Orleans, LA 70112 USA
[3] Mem Sloan Kettering Canc Ctr, Dept Pathol, Cytol Serv, New York, NY 10021 USA
[4] Louisiana State Univ, Hlth Sci Ctr, Dept Surg, New Orleans, LA 70112 USA
[5] Wake Forest Univ, Sch Med, Dept Surg, Winston Salem, NC 27157 USA
[6] Louisiana State Univ, Biol Computat & Visualizat Ctr, Dept Biol Sci, Baton Rouge, LA 70803 USA
关键词
mobile element; identical by descent; breast cancer;
D O I
10.1016/S0027-5107(02)00015-5
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A polymorphic Alu element belonging to the young Ya5 subfamily of Alu repeats located in the progesterone receptor gene has been characterized. Using a polymerase chain reaction (PCR)-based assay, the genetic diversity associated with the PROGINS Alu repeat was determined in a diverse array of human populations. The level of insertion polymorphism associated with PROGINS suggests that it will be a useful marker for the study of human evolution. In addition, we determined the distribution of the PROGINS Alu insertion in two groups of women from greater New Orleans, LA with breast cancer. The PROGINS Alu insertion was not associated with breast cancer in the populations tested. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:137 / 141
页数:5
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