Controlled-Release Systems for Metal-Based Nanomedicine: Encapsulated/Self-Assembled Nanoparticles of Anticancer Gold(III)/Platinum(II) Complexes and Antimicrobial Silver Nanoparticles

被引：72
|
作者：
Lok, Chun-Nam [1 ,2 ]
Zou, Taotao [1 ,2 ]
Zhang, Jing-Jing [1 ,2 ]
Lin, Iris Wing-Shan [1 ,2 ]
Che, Chi-Ming [1 ,2 ,3 ]
机构：
[1] Univ Hong Kong, Inst Mol Funct Mat, State Key Lab Synthet Chem, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
[3] HKU Shenzhen Inst Res & Innovat, Shenzhen 518053, Peoples R China
来源：
ADVANCED MATERIALS | 2014年 / 26卷 / 31期
关键词：
SUPRAMOLECULAR POLYMERS; ANTIBACTERIAL ACTIVITY; NANOSILVER; TOXICITY; DELIVERY; HYDROGELATION; NANOCARRIERS; DISSOLUTION; NANOFIBERS; IONS;
D O I：
10.1002/adma.201305617
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The therapeutic applications of many anticancer or antimicrobial metal complexes often suffer from low solubility and low stability in physiological conditions or from drug resistance. To circumvent these problems, nanoparticle systems that allow controlled release and specific accumulation in the targeted disease tissue are of advantage for efficient treatment with minimal toxicity. The focus of this Research News is metal-based nanomaterials comprising anticancer gold(III)/platinum(II) complexes or antimicrobial silver, highlighting the controlled-release properties of self-assembled metal systems.
引用
收藏
页码：5550 / 5557
页数：8
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