Role of Donepezil in the Management of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia with Lewy Bodies

被引：101
|
作者：
Cummings, Jeffrey [1 ]
Lai, Te-Jen [2 ]
Hemrungrojn, Solaphat [3 ]
Mohandas, E. [4 ]
Kim, Sang Yun [5 ,6 ]
Nair, Girish [7 ]
Dash, Amitabh [8 ]
机构：
[1] Cleveland Clin Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA
[2] Chung Shan Med Univ, Inst Med, Chung Shan Med Univ Hosp, Dept Psychiat, Taichung 40201, Taiwan
[3] Chulalongkorn Univ, Fac Med, King Chulalongkorn Mem Hosp, Dept Psychiat, Bangkok 10330, Thailand
[4] Sun Med & Res Ctr, Dept Psychol Med, Trichur, Kerala, India
[5] Seoul Natl Univ, Coll Med, Dept Neurol, Seoul, South Korea
[6] Seoul Natl Univ, Bundang Hosp, Seoul, South Korea
[7] Fortis Hosp Mahim, Dept Neurol, Mumbai, Maharashtra, India
[8] Eisai & Co Ltd, Mumbai, Maharashtra, India
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2016年 / 22卷 / 03期
关键词：
Alzheimer disease; Behavioral symptoms; Cholinesterase inhibitors; Dementia; Donepezil; ATYPICAL ANTIPSYCHOTIC MEDICATIONS; CHOLINESTERASE INHIBITOR THERAPY; PSYCHOLOGICAL SYMPTOMS; BEHAVIORAL SYMPTOMS; DOUBLE-BLIND; EFFICACY; SAFETY; MODERATE; RIVASTIGMINE; METAANALYSIS;
D O I：
10.1111/cns.12484
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is a progressive condition that affects cognition, function, and behavior. Approximately 60-90% of patients with AD develop neuropsychiatric symptoms (NPS) such as hallucinations, delusions, agitation/aggression, dysphoria/depression, anxiety, irritability, disinhibition, euphoria, apathy, aberrant motor behavior, sleep disturbances, appetite and eating changes, or altered sexual behavior. These noncognitive behavior changes are thought to result from anatomical and biochemical changes within the brain, and have been linked, in part, to cholinergic deficiency. Cholinesterase inhibitors may reduce the emergence of NPS and have a role in their treatment. These agents may delay initiation of, or reduce the need for, other drugs such as antipsychotics. This article summarizes the effects of donepezil, a cholinesterase inhibitor, on the NPS of dementia with emphasis on AD and dementia with Lewy bodies.
引用
收藏
页码：159 / 166
页数：8
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