Protein misfolding and prion diseases

被引：130

作者：

Cohen, FE ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1999年 / 293卷 / 02期

基金：

美国国家卫生研究院;

关键词：

prion; protein folding; Creutzfeldt-Jakob disease; Alzheimer's disease;

D O I：

10.1006/jmbi.1999.2990

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prion diseases provide an intriguing connection between protein folding and neurodegenerative disease. In this review, I explore that importance of protein folding and misfolding in the prion diseases. Thermodynamic and kinetic models are examined in an effort to understand infectious, inherited and sporadic forms of these diseases. These concepts can be generalized to gain insight into other disorders of protein aggregation and deposition such as Alzheimer's disease. (C) 1999 Academic Press.

引用

页码：313 / 320

页数：8

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