Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species

被引：22
|
作者：
Abdel-Sattar, Essam [1 ]
Shehab, Naglaa G. [2 ]
Ichino, Chikara [3 ]
Kiyohara, Hiroaki [3 ]
Ishiyama, Aki [4 ]
Otoguro, Kazuhiko [4 ]
Omura, Satoshi [3 ]
Yamada, Haruki [3 ]
机构：
[1] King Abdulaziz Univ, Dept Nat Prod & Alternat Med, Fac Pharm, Jeddah 21589, Saudi Arabia
[2] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt
[3] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan
[4] Kitasato Univ, Res Ctr Trop Dis, Minato Ku, Tokyo 1088641, Japan
来源：
PHYTOMEDICINE | 2009年 / 16卷 / 6-7期
关键词：
Caralluma penicillata; Caralluma russelliana; Caralluma tuberculata; Asclepiadaceae; Penicillosides; Russeliosides; Caratubersides; Antitrypanosomal activity; Cytotoxicity; OXYPREGNANE GLYCOSIDES; PLANTS; ASSAY;
D O I：
10.1016/j.phymed.2009.02.009
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Pregnane glycosides previously isolated from genus Caralluma (C Penicillata, C tuberculata and C russelliana) were tested for their anti trypanosoma I activity. Penicilloside E showed the highest antitrypanosomal activity (IC50 1.01 mu g/ml) followed by caratuberside C (IC50 1.85 mu g/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity. (C) 2009 Elsevier GmbH. All rights reserved.
引用
收藏
页码：659 / 664
页数：6
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