Using models to explore whole-body metabolism and accessing models through a model library

被引:7
|
作者
Wastney, ME
Subramanian, KNS
Broering, N
Boston, R
机构
[1] GEORGETOWN UNIV, MED CTR, MED CTR LIB, WASHINGTON, DC 20007 USA
[2] UNIV PENN, SCH MED, KENNETT SQ, PA USA
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1997年 / 46卷 / 03期
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0026-0495(97)90261-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A model is a mathematical representation of a system that can be used to explore the system in a number of ways: to determine the system's internal connections, to calculate properties of the system such as flow rates and pool sizes, and to make predictions about the system's behavior under different conditions. The use of modeling to explore whole-body metabolism is demonstrated using a compartmental model of zinc kinetics as an example. Because models are useful tools for exploring systems, a facility called a ''model library'' is being established on the Internet to provide access to working versions of published models. Copyright (C) 1997 by W.B. Saunders Company.
引用
收藏
页码:330 / 332
页数:3
相关论文
共 50 条
  • [1] Understanding the metabolism of infants using whole-body metabolic models
    Lee, Sang Yup
    Kim, Gi Bae
    CELL METABOLISM, 2024, 36 (08) : 1641 - 1643
  • [2] Personalized whole-body models integrate metabolism, physiology, and the gut microbiome
    Thiele, Ines
    Sahoo, Swagatika
    Heinken, Almut
    Hertel, Johannes
    Heirendt, Laurent
    Aurich, Maike K.
    Fleming, Ronan M. T.
    MOLECULAR SYSTEMS BIOLOGY, 2020, 16 (05)
  • [3] Whole-body physiologically based pharmacokinetic models
    Nestorov, Ivan
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2007, 3 (02) : 235 - 249
  • [4] Lumping of whole-body physiologically based pharmacokinetic models
    Nestorov, IA
    Aarons, LJ
    Arundel, PA
    Rowland, M
    JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1998, 26 (01): : 21 - 46
  • [5] Noncompartmental models of whole-body clearance of tracers: A review
    Kenneth H. Norwich
    Annals of Biomedical Engineering, 1997, 25 : 421 - 439
  • [6] The critical power and related whole-body bioenergetic models
    Morton, RH
    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2006, 96 (04) : 339 - 354
  • [7] Noncompartmental models of whole-body clearance of tracers: A review
    Norwich, KH
    ANNALS OF BIOMEDICAL ENGINEERING, 1997, 25 (03) : 421 - 439
  • [8] MODELS FOR PREDICTION OF WHOLE-BODY PLETHYSMOGRAPHIC MEASUREMENTS IN INFANTS
    KRAEMER, R
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (04): : A221 - A221
  • [9] Lumping of Whole-Body Physiologically Based Pharmacokinetic Models
    Ivan A. Nestorov
    Leon J. Aarons
    Philip A. Arundel
    Malcolm Rowland
    Journal of Pharmacokinetics and Biopharmaceutics, 1998, 26 : 21 - 46
  • [10] The critical power and related whole-body bioenergetic models
    R. Hugh Morton
    European Journal of Applied Physiology, 2006, 96 : 339 - 354