Dengue 1 Virus and Dengue Hemorrhagic Fever, French Polynesia, 2001

被引：18
|
作者：
Hubert, Bruno [1 ]
Halstead, Scott B. [2 ]
机构：
[1] Directorate Hlth, Papeete, Tahiti, France
[2] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA
来源：
EMERGING INFECTIOUS DISEASES | 2009年 / 15卷 / 08期
关键词：
EASTER-ISLAND; ANTIBODY; CUBA; PATHOGENESIS; THAILAND;
D O I：
10.3201/eid1508.081500
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An epidemic of dengue 1 virus (DENV-1) occurred in French Polynesia in 2001, 4 years after a DENV-2 epidemic that ended in 1997. Surveillance data from hospitalized case-patients showed that case-patients with dengue hemorrhagic fever (DHF) exhibited a bimodal age distribution with 1 peak among infants 6-10 months of age and a second peak at 4-11 years of age. The relative risk of DHF developing in children born before rather than after the DENV-2 epidemic was 186 (95% confidence interval 26-1,324). Among children born toward the end of the DENV-2 epidemic, a strong temporal association was found between the month of birth and the risk of being hospitalized for DHF. This study documents epidemic pathogenicity associated with the sequence of DENV-2 infection followed by DENV-1 infection.
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收藏
页码：1265 / 1270
页数：6
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