Mass and charge distributions of amyloid fibers involved in neurodegenerative diseases: mapping heterogeneity and polymorphism

被引：27

作者：

Pansieri, Jonathan ^{[1
]}

Halim, Mohammad A. ^{[2
]}

Vendrely, Charlotte ^{[3
]}

Dumoulin, Mireille ^{[4
]}

Legrand, Francois ^{[4
,5
]}

Sallanon, Marcelle Moulin ^{[6
]}

Chierici, Sabine ^{[7
]}

Denti, Simona ^{[6
]}

Dagany, Xavier ^{[2
]}

Dugourd, Philippe ^{[2
]}

Marquette, Christel ^{[1
]}

Antoine, Rodolphe ^{[2
]}

Forge, Vincent ^{[1
]}

机构：

[1] Univ Grenoble Alpes, CNRS, CEA, BIG,CBM,AFFOND, F-38000 Grenoble, France

[2] Univ Claude Bernard Lyon 1, CNRS, UMR 5306, Inst Lumiere Matiere, F-69622 Lyon, France

[3] Univ Cergy Pontoise, I MAT FD4122, ERRMECe, F-95302 Cergy Pontoise, France

[4] Univ Liege, InBIOS, Ctr Prot Engn, Enzymol & Prot Folding, B-4000 Liege 1, Belgium

[5] Haute Ecole Libre Mosane, Ctr Rech, Inst Grp, Mt St Martin 41, B-4000 Liege, Belgium

[6] INSERM, U1039, Radiopharmaceut Bioclin, Fac Med Grenoble, F-38700 La Tronche, France

[7] Univ Grenoble Alpes, CNRS, UMR 5250, Dept Clin Mol, F-38000 Grenoble, France

来源：

CHEMICAL SCIENCE | 2018年 / 9卷 / 10期

基金：

欧洲研究理事会;

关键词：

SECONDARY NUCLEATION; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; SPECTROMETRY; FIBRILS; VIRUS; OLIGOMERS; ASSEMBLIES; RESOLUTION; MECHANISM;

D O I：

10.1039/c7sc04542e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heterogeneity and polymorphism are generic features of amyloid fibers with some important effects on the related disease development. We report here the characterization, by charge detection mass spectrometry, of amyloid fibers made of three polypeptides involved in neurodegenerative diseases: A beta(1-42) peptide, tau and alpha-synuclein. Beside the mass of individual fibers, this technique enables to characterize the heterogeneity and the polymorphism of the population. In the case of A beta(1-42) peptide and tau protein, several coexisting species could be distinguished and characterized. In the case of alpha-synuclein, we show how the polymorphism affects the mass and charge distributions.

引用

页码：2791 / 2796

页数：6

共 4 条

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