Microwave assisted synthesis of 5-hydroxy-5-trichloromethyl-4,5-dihydroisoxazoles

被引：31

作者：

Martins, MAP ^{[1
]}

Beck, P ^{[1
]}

Cunico, W ^{[1
]}

Pereira, CMP ^{[1
]}

Sinhorin, AP ^{[1
]}

Blanco, RF ^{[1
]}

Peres, R ^{[1
]}

Bonacorso, HG ^{[1
]}

Zanatta, N ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, BR-105900 Santa Maria, RS, Brazil

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 39期

关键词：

microwave irradiations; isoxazoles; enones; halogen compounds;

D O I：

10.1016/S0040-4039(02)01555-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 13 5-hydroxy-5-trichloromethyl-4,5-dihydroisoxazoles have been synthesized in 78-96% yield by environmentally benign microwave induced techniques involving the cyclocondensation of 4-alkoxy-1,1,1-trichloro-3-alken-2-ones [CCl3C(O)C(R-2)=C(R-1)OR, where R-2=H, alkyl; R-1=H, alkyl, aryl and R=H, alkyl] with hydroxylamine using toluene as solvent. The advantages obtained by the use of microwave irradiation in relation to a classical method were demonstrated. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7005 / 7008

页数：4

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