Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia

Objective:To investigate the expression of plasma NF-kappa B and the inhibitory subunit I kappa B-alpha in HIV-associated pre-eclampsia. Method: This retrospective study examined plasma NF-kappa B and I kappa B-alpha expression expressed as Mean Fluorescence Intensity (MFI) in normotensive (n = 32) and pre-eclamptic (n = 34) pregnant women stratified by HIV status. Results: A significant decrease in the level of plasma NF-kappa B expression between pre-eclamptic and normotensive pregnant women was observed, irrespective of HIV status (MFI = 82.8 vs 134.3; p = 0.03). Similarly, a significant decline in the level of plasma I kappa B-alpha expression was noted in the pre-eclamptic compared to normotensive pregnant women, irrespective of HIV status (MFI = 91.2 vs 120.1; p = 0.04). Plasma NF-kappa B (p = 0.7) and I kappa B-alpha (p = 0.8) expression was similar between HIV positive and HIV negative pregnant women, irrespective of pregnancy type. Conclusion: This study demonstrates decreased plasma NF-kappa B and I kappa B-alpha expression in preeclampsia compared to normotensive pregnant women irrespective of HIV status.