Generation of an integration-free induced pluripotent stem cell line (JTUi004-A) from an otosclerosis patient

被引：0
|
作者：
Wu, Hongmin [1 ,2 ]
Fang, Jia [1 ,2 ]
Liu, Yaoqian [1 ,2 ]
Wang, Jingjing [1 ,2 ]
Chen, Zhengnong [1 ,2 ]
Wang, Jiping [1 ,2 ]
Shi, Haibo [1 ,2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Otolaryngol Head & Neck Surg, Shanghai 200233, Peoples R China
[2] Shanghai Jiao Tong Univ, Otolaryngol Inst, Shanghai 200233, Peoples R China
[3] Shanghai Key Lab Sleep Disordered Breathing, Shanghai 200233, Peoples R China
来源：
STEM CELL RESEARCH | 2022年 / 61卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2022.102783
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Otosclerosis is caused by abnormal bone remodeling in the middle ear, resulting in progressive hearing loss, dizziness, balance problems, and tinnitus. Previous infection, stress fractures of the bony tissue surrounding the inner ear, immune disorders, and genetic factors are believed to contribute to this disease. Currently, no effective drug treatment for otosclerosis is known. Herein, we generated an induced pluripotent stem cell line from the peripheral blood mononuclear cells of an otosclerosis patient. The cell line exhibited normal morphology, karyotype, and pluripotency marker expression. A teratoma assay revealed successful differentiation into all three germ layers.
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页数：4
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