Bone morphogenetic proteins in human bone regeneration

被引:310
|
作者
Groeneveld, EHJ [1 ]
Burger, EH [1 ]
机构
[1] Free Univ Amsterdam, ACTA, Dept Oral Cell Biol, NL-1081 BT Amsterdam, Netherlands
关键词
D O I
10.1530/eje.0.1420009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4). Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. Animal studies and laboratory experiments reveal a number of conditions that influence the osteoinductivity of BMP, such as BMP concentration, carrier properties and influence of local and systemic growth factors and hormones. In this paper, these studies and the clinical reports are reviewed, and the conditions that modulate the BMP-dependent osteoinduction are discussed. The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be improved.
引用
收藏
页码:9 / 21
页数:13
相关论文
共 50 条
  • [1] Bone Morphogenetic Proteins for Bone Regeneration and Their Alternatives
    Laurencin, Cato T.
    Lo, Kevin W. -H.
    CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (19) : 3353 - 3353
  • [2] Regeneration of the skeleton by recombinant human bone morphogenetic proteins
    Smoljanovic, Tomislav
    Grgurevic, Lovorka
    Jelic, Mislav
    Kreszinger, Mario
    Haspl, Miroslav
    Maticic, Drazen
    Vukicevic, Slobodan
    Pecina, Marko
    COLLEGIUM ANTROPOLOGICUM, 2007, 31 (03) : 923 - 932
  • [3] BONE MORPHOGENETIC PROTEINS: A NEW VISTA IN BONE REGENERATION
    Sreedhar, Muktevi
    JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS, 2014, 3 (20): : 5448 - 5452
  • [4] Use of bone morphogenetic proteins for augmentation of bone regeneration
    Kirker-Head, Carl A.
    Kraus, Karl H.
    JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2007, 231 (07): : 1039 - 1055
  • [5] Bone morphogenetic proteins: Signaling periodontal bone regeneration and repair
    Anusuya, G. Sai
    Kandasamy, M.
    Raja, S. A. Jacob
    Sabarinathan, S.
    Ravishankar, P.
    Kandhasamy, Balu
    JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2016, 8 : 39 - 41
  • [6] Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
    Krouwels, Anita
    Iljas, Juvita D.
    Kragten, Angela H. M.
    Dhert, Wouter J. A.
    Oner, F. Cumhur
    Tryfonidou, Marianna A.
    Creemers, Laura B.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
  • [7] Tissue morphogenesis and regeneration by bone morphogenetic proteins
    Ripamonti, U
    Duneas, N
    PLASTIC AND RECONSTRUCTIVE SURGERY, 1998, 101 (01) : 227 - 239
  • [8] Bone morphogenetic proteins for articular cartilage regeneration
    Deng, Z. H.
    Li, Y. S.
    Gao, X.
    Lei, G. H.
    Huard, J.
    OSTEOARTHRITIS AND CARTILAGE, 2018, 26 (09) : 1153 - 1161
  • [9] Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration
    Inas El Bialy
    Wim Jiskoot
    M. Reza Nejadnik
    Pharmaceutical Research, 2017, 34 : 1152 - 1170
  • [10] Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers
    Sheikh, Zeeshan
    Javaid, Mohammad Ahmad
    Hamdan, Nader
    Hashmi, Raheel
    MATERIALS, 2015, 8 (04) : 1778 - 1816