Total synthesis of a sialylated and sulfated oligosaccharide from O-linked glycoproteins

被引：17
|
作者：
Xia, J [1 ]
Piskorz, CF [1 ]
Alderfer, JL [1 ]
Locke, RD [1 ]
Matta, KL [1 ]
机构：
[1] Roswell Pk Canc Inst, Buffalo, NY 14263 USA
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 16期
关键词：
D O I：
10.1016/S0040-4039(00)00261-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of a sialylated and sulfated oligosaccharide 1 representative of a structure occurring in respiratory mucins has been accomplished. Our strategy depends upon the employment of 2-naphthymethyl (NAP) protection for hydroxyl functions. Choice of the well-defined sialyl donor 15 was made because of its enhanced reactivity over the parent compound 14 for glycosylation. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2773 / 2776
页数：4
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