Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures

被引：20

作者：

Tominari, Tsukasa ^{[1
,2
]}

Matsumoto, Chiho ^{[1
]}

Watanabe, Kenta ^{[1
]}

Hirata, Michiko ^{[1
]}

Grundler, Florian M. W. ^{[2
,3
]}

Inada, Masaki ^{[1
,2
]}

Miyaura, Chisato ^{[1
,2
]}

机构：

[1] Tokyo Univ Agr & Technol, Dept Biotechnol & Life Sci, Tokyo, Japan

[2] Tokyo Univ Agr & Technol, Inst Global Innovat Res, Tokyo, Japan

[3] Univ Bonn, Inst Crop Sci & Resource Conservat, Bonn, Germany

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 02期

关键词：

bone resorption; bone formation; xantho-phyll family of carotenoids; PATHWAY;

D O I：

10.1080/09168451.2016.1243983

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature osteoclasts was also suppressed by lutein in cultures. When lutein was added to the cultures of osteoblasts, lutein enhanced the formation of mineralized bone nodules by elevating BMP2 expression and inhibiting sclerostin expression. Lutein may be beneficial for bone health.

引用

页码：302 / 306

页数：5

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