Micro Strip Line-Based On-Chip Terahertz Integrated Devices for High Sensitivity Biosensors

被引：20

作者：

Kasai, Shintaro ^{[1
]}

Tanabashi, Akihiro ^{[2
]}

Kajiki, Kosuke ^{[1
]}

Itsuji, Takeaki ^{[1
]}

Kurosaka, Ryoji ^{[1
]}

Yoneyama, Haruko ^{[2
]}

Yamashita, Masatsugu ^{[2
]}

Ito, Hiromasa ^{[2
]}

Ouchi, Toshihiko ^{[1
]}

机构：

[1] Canon Inc, Frontier Res Ctr, Ota Ku, Tokyo 1468501, Japan

[2] RIKEN, Terahertz Biol Sensing Res Lab, Wako, Saitama 3510198, Japan

来源：

APPLIED PHYSICS EXPRESS | 2009年 / 2卷 / 06期

关键词：

DNA;

D O I：

10.1143/APEX.2.062401

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We have achieved label free DNA hybridization detection at the level of a few femto-moles using on-chip terahertz (THz) integrated devices. The devices consist of two photoconductive switches for the generation and detection of THz pulses. A DNA specimen placed in a reservoir on the micro strip line (MSL) connecting the switches delays the propagating THz pulses. Different delay times were observed depending on the DNA conformation. The high sensitivity achieved is due to MSL design adjustment and the use of a specimen reservoir. Both simulations and experimental results indicate that devices with a narrower MSL have higher sensitivity. (C) 2009 The Japan Society of Applied Physics

引用

页数：3

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