Metformin Inhibits Tumor Cell Migration via Down-regulation of MMP9 in Tamoxifen-resistant Breast Cancer Cells

被引：0
|
作者：
Jang, Soon Young [1 ]
Kim, Aeree [1 ,2 ]
Kim, Jin Kyoung [1 ,2 ]
Kim, Chungyel [1 ,2 ]
Cho, Youl-Hee [3 ]
Kim, Jong-Ho [4 ]
Kim, Chul Hwan [1 ]
Lee, Ji-Yun [1 ]
机构：
[1] Korea Univ, Coll Med, Dept Pathol, Seoul 136705, South Korea
[2] Korea Univ, Guro Hosp, Dept Pathol, Seoul, South Korea
[3] Hanyang Univ, Coll Med, Dept Med Genet, Seoul 133791, South Korea
[4] Kyung Hee Univ, Coll Pharm, Dept Pharmaceut Sci, Seoul, South Korea
来源：
ANTICANCER RESEARCH | 2014年 / 34卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
Metformin; MMP9; tamoxifen resistance; invasion; migration; MATRIX METALLOPROTEINASES; GELATINASE-B; MATRIX-METALLOPROTEINASE-9; EXPRESSION; METASTASIS; MECHANISMS; INVASION; GROWTH; ACTIVATION; PATHWAY;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metformin is the most widely used anti-diabetic drug in the world. Recent evidence indicates that metformin could potentially inhibit tumorigenesis. In the present study, we found that metformin inhibited cell migration and invasion of phorbol 12-myristate 13-acetate-induced MCF-7 and tamoxifen-resistant MCF-7 breast cancer cells. This inhibition was correlated with the modulation of matrix metalloproteinase-9 (MMP9) via the suppression of its expression and proteolytic activity. These results indicate that metformin leads to the suppression of migration and invasion through regulation of MMP9 and it may have potential as an anticancer drug for therapy in human breast cancer, especially of chemoresistant cancer cells.
引用
收藏
页码：4127 / 4134
页数：8
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