Synthesis, Spectroscopic and Biological Studies of Transition Metal Complexes of Novel Schiff Bases Derived from Amoxicillin and Sugars

被引：0

作者：

Naz, Narjis ^{[2
]}

Iqbal, Muhammad Zafar ^{[1
]}

机构：

[1] Univ Hlth Sci, Lahore, Pakistan

[2] Women Univ, Lahore Coll, Dept Chem, Lahore, Pakistan

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2009年 / 31卷 / 03期

关键词：

ZINC(II) COMPLEXES; ANTIMICROBIAL ACTIVITIES; ANTIFUNGAL ACTIVITY; CIRCULAR-DICHROISM; NI(II) COMPLEXES; CU(II) COMPLEXES; CO(II); ANTIBACTERIAL; COPPER(II); ZN(II);

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fe (II), Co (II) and Ni (II) metal complexes of new Schiff bases derived from amoxicillin with sugars (D-Glucose, D-Galactose and D-Mannose) have been synthesized and characterized by elemental analysis, FTIR, electronic absorption, and atomic absorption spectroscopy, magnetic moment measurements and thermal analysis. It has been found that Schiff bases behave as bi-dentate ligands forming complexes with 1:2 (metal:ligand) stoichiometry, The complexes were neutral as confirmed by their low conductance values. The biological applications of complexes have been studied on two gram negative (Escherichia coli and Pseudomonas aeruginosa) and two gram positive (Bacillus subtilis and Staphylococcus aureus) microorganisms by Agar diffusion disc method. It has been found that all the complexes have higher biological activities than the pure amoxicillin.

引用

页码：440 / 446

页数：7

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