Nanoprodrugs encapsulated with mesoporous silica nanoparticles for combined with photothermal therapy for the treatment and care of gastric cancer

In this study, mesoporous silica nanoparticles ( MSNs) were surface-modified with polymer poly (HEMA-co-PEGMA via surface-initiated atom transfer radical polymerization and a multifunctional nanoplatform MSNP@poly(HEMA-co-PEGMA-g-doxorubicin (DOX)/Rhodamine 6 G(R6G) was developed to combine photothermal (PTT) and chemotherapy therapy effectively. PTT induced by near-infrared (NIR) radiations might further destroy gastric cancer cell lines while the small-dye molecule was co-loaded into theMSNPpores. A 65% higher cumulative drug release over 50-h occurs when the cis-aconitic anhydride link breaks under low-pH stimulation (typical physiological environment). High temperatures accelerated reversible covalent bond breakage. The accumulative release of the drug increased by 24.3 %, illustrating that higher temperatures can decrease the time needed to complete blood drug concentrations by 24.3 %. More than 90% of gastric tumour cells were destroyed after 48 h following exposure to NIR light irradiation with the prodrug delivery system, compared toDOXalone in vitro cytotoxicity tests. Because of this, rapidly reversible chemical bond breaking and photothermal activity in MSNP@poly(HEMA-co-PEGMA-g-DOX/R6G) increased the synergic impact of the chemotherapy, which offers tremendous promise in combination with the treatment and care of gastric cancer therapy.