Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients

被引：5

作者：

Huang, Yadi ^{[1
]}

Boerema-de Munck, Anne ^{[1
,2
]}

Buscop-van Kempen, Marjon ^{[1
,2
]}

Sluiter, Ilona ^{[1
]}

de Krijger, Ronald ^{[3
,4
]}

Tibboel, Dick ^{[1
]}

Rottier, Robbert J. ^{[1
,2
]}

机构：

[1] Erasmus MC Sophia Childrens Hosp, Dept Pediat Surg, Rotterdam, Netherlands

[2] Erasmus MC, Dept Cell Biol, Rotterdam, Netherlands

[3] Reinier de Graaf Hosp, Dept Pathol, Delft, Netherlands

[4] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

来源：

PULMONARY CIRCULATION | 2018年 / 8卷 / 03期

关键词：

hypoxia inducible factor; pulmonary hypertension; pulmonary vascular development and epithelium; EXPRESSION; CELLS; AXIS; MICE;

D O I：

10.1177/2045894018783734

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We show that hypoxia inducible factor 2 alpha(HIF2 alpha) is highly expressed in patients with pulmonary hypertension (PH). HIF2 alpha is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2 alpha. Our data suggest that HIF2 alpha is a link between hypoxia and the development of PH.

引用

页数：4

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