An efficient method for the N-formylation of amines under catalyst- and additive-free conditions

被引：5
|
作者：
Xu, Zhuo-Wei [1 ]
Xu, Wen-Yi [1 ]
Pei, Xiao-Jun [1 ]
Tang, Fei [1 ]
Feng, Yi-Si [1 ,2 ]
机构：
[1] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China
[2] Anhui Prov Lab Heterocycl Chem, Maanshan 243110, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 18期
基金：
中国国家自然科学基金;
关键词：
N-formylation; Catalyst- and additive-free; Environment-friendly; Organic synthesis; CARBON-DIOXIDE; SECONDARY-AMINES; TRANSAMIDATION; AMIDES; ACIDS; CO2; CARBOXAMIDES; ALCOHOLS; FORMAMIDES; HYDROSILANE;
D O I：
10.1016/j.tetlet.2019.03.071
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives. A mechanism that involves difluorocarbene is proposed for this reaction. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1254 / 1258
页数：5
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