Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya

被引：14

作者：

Inzaule, Seth C. ^{[1
,2
,3
]}

Hamers, Raph L. ^{[1
,2
,4
]}

Mukui, Irene ^{[5
]}

Were, Kennedy ^{[3
]}

Owiti, Prestone ^{[3
]}

Kwaro, Daniel ^{[3
]}

de Wit, Tobias F. Rinke ^{[1
,2
]}

Zeh, Clement ^{[6
]}

机构：

[1] Acad Med Ctr, Dept Global Hlth, Amsterdam, Netherlands

[2] Amsterdam Inst Global Hlth & Dev, Pietersbergweg 17, NL-1105 BM Amsterdam, Netherlands

[3] Kenya Govt Med Res Ctr, Kisumu, Kenya

[4] Univ Amsterdam, Acad Med Ctr, Div Infect Dis, Dept Internal Med, Amsterdam, Netherlands

[5] Natl AIDS & STI Control Programme, Nairobi, Kenya

[6] US Ctr Dis Control & Prevent, Kisumu, Kenya

来源：

AIDS | 2017年 / 31卷 / 10期

关键词：

ANTIRETROVIRAL DRUG-RESISTANCE; ADULTS;

D O I：

10.1097/QAD.0000000000001500

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We performed a countrywide assessment of HIV drug resistance among 123 patients with virological failure on second-line antiretroviral therapy (ART) in Kenya. The percentage of patients harbouring intermediate-to-high-level resistance was 27% for lopinavir-ritonavir, 24% for atazanavir-ritonavir and 7% for darunavir-ritonavir, and 25% had complete loss of activity to all available first and second-line drugs. Overall, one in four patients failing second-line ART have completely exhausted available antiretrovirals in Kenya, highlighting the need for increased access to third-line drugs.

引用

页码：1495 / 1498

页数：4

共 50 条

[1] HIV-1 Drug Resistance and Third-Line Therapy Outcomes in Patients Failing Second-Line Therapy in Zimbabwe
Chimbetete, Cleophas
Katzenstein, David
Shamu, Tinei
Spoerri, Adrian
Estill, Janne
Egger, Matthias
Keiser, Olivia
OPEN FORUM INFECTIOUS DISEASES, 2018, 5 (02):
[2] Resistance to second-line drugs in multidrug-resistant tuberculosis
Nyang'wa, Bern-Thomas
Brigden, Grania
du Cros, Philipp
Shanks, Leslie
LANCET, 2013, 381 (9867): : 625 - 625
[3] Multidrug-resistant HIV-1 - Reply
Gandhi, RT
CLINICAL INFECTIOUS DISEASES, 2004, 38 (10) : 1512 - 1512
[4] Resistance to second-line drugs in multidrug-resistant tuberculosis Reply
Dalton, Tracy
Cegielski, Peter
Kurbatova, Ekaterina
Ershova, Julia
Campos Caoili, Janice
LANCET, 2013, 381 (9867): : 626 - 626
[5] Antiretroviral Resistance patterns in HIV-1 infected patients failing to second-line in Bamako, Mali
Maiga, A. I.
Traore, F. T.
Dolo, O.
Togo, J.
Calvez, V.
Katlama, C.
Marcelin, A-G
HIV MEDICINE, 2019, 20 : 175 - 176
[6] Microbicides for multidrug-resistant and multitropic HIV-1
D'Cruz, Osmond J.
Uckun, Fatih M.
CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2008, 9 (02) : 152 - 169
[7] Standardised second-line treatment of multidrug-resistant tuberculosis during pregnancy
Tabarsi, P.
Moradi, A.
Baghaei, P.
Marjani, M.
Shamaei, M.
Mansouri, N.
Chitsaz, E.
Farnia, P.
Mansouri, D.
Masjedi, M.
Velayati, A.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2011, 15 (04) : 547 - 550
[8] HIV-1 drug resistance and third-line outcomes among children and adolescents failing second-line therapy in Malawi
Lee, L.
Mbingwani, I.
Kalua, T.
Spiers, S.
Duranti, S.
Schramm, B.
Kamba, R.
Szumilin, E.
Salumu, L.
Maman, D.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2019, 22 : 83 - 83
[9] Antiviral activity of lamivudine in salvage therapy for multidrug-resistant HIV-1 infection
Campbell, TB
Shulman, NS
Johnson, SC
Zolopa, AR
Young, RK
Bushman, L
Fletcher, CV
Lanier, ER
Merigan, TC
Kuritzkes, DR
CLINICAL INFECTIOUS DISEASES, 2005, 41 (02) : 236 - 242
[10] Viral escape in the CNS with multidrug-resistant HIV-1
Beguelin, Charles
Vazquez, Miriam
Bertschi, Manuel
Yerly, Sabine
de Jong, Denise
Rauch, Andri
Cusini, Alexia
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2014, 17 : 156 - 157

← 1 2 3 4 5 →