An improved overall risk probability-based method for assessing the combined health risks of chemical mixtures: An example about mixture of aflatoxin B1 and microcystin LR by dietary intake

被引：4

作者：

Li, Yun ^{[1
,2
]}

Wang, JiaSheng ^{[1
]}

Li, JinJuan ^{[2
]}

Sun, XiuLan ^{[1
]}

机构：

[1] Jiangnan Univ, Synerget Innovat Ctr Food Safety & Nutr, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[2] Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Safety & Qual, Minist Agr, 12 Zhongguancun South St, Beijing 100081, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 146卷

基金：

中国国家自然科学基金;

关键词：

Probabilistic assessment; An improved overall risk probability-based method; Combined toxicity factor; Aflatoxin B-1; Microcystin LR; MAXIMUM-LIKELIHOOD; TOXICITY; SIMULATION; MODELS; TESTS;

D O I：

10.1016/j.fct.2020.111815

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Previous studies on the risk assessment of chemicals with respect to human health have focused mainly on the safety of individual substances. Recently, public health policy emphasizes the combined effects of mixtures. An overall risk probability (ORP)-based method long with the combined toxicity factor (c(uv)) can be used to evaluate the combined toxicity of chemical mixtures from the environment and foods on human health. However, the procedure for calculating the c(uv) accurately and quantitatively in the ORP method is yet unclear. In this study, an improved ORP-based method (IORP) was developed by introducing a variable time t, and the c(uv) was analyzed quantitatively using simultaneous equations and based on the principle of least squares regression. This phenomenon can be explained based on the example of the mixture of aflatoxin B-1 (AFB(1)) and microcystin LR (MC-LR) by dietary intake in order to understand the application of this method. The IORP approach makes it possible for estimating the combined effects of mixtures for human health by dietary pathway.

引用

页数：10