Metabotropic receptors for glutamate and GABA in pain

被引：142

作者：

Goudet, Cyril ^{[1
,7
]}

Magnaghi, Valerio ^{[2
,3
]}

Landry, Marc ^{[4
,5
]}

Nagy, Frederic ^{[4
,5
]}

Gereau, Robert W. ^{[6
]}

Pin, Jean-Philippe ^{[7
]}

机构：

[1] Univ Montpellier I, INSERM, CNRS, UMR5203,U661,Inst Genom Fonctionnelle, F-34094 Montpellier 5, France

[2] Univ Milan, Dept Endocrinol, I-20122 Milan, Italy

[3] Univ Milan, Ctr Excellence Neurodegenerat Dis, I-20122 Milan, Italy

[4] Inst Francois Magendie, INSERM, U 862, F-33077 Bordeaux, France

[5] Univ Bordeaux 2, F-33076 Bordeaux, France

[6] Washington Univ, Sch Med, Dept Anesthesiol, Pain Ctr, St Louis, MO 63110 USA

[7] Univ Montpellier 2, Inst Genom Fonctionnelle, CNRS, UMR5203, F-34094 Montpellier 5, France

来源：

BRAIN RESEARCH REVIEWS | 2009年 / 60卷 / 01期

关键词：

Pain; Glutamate; GABA; GPCR; DORSAL-HORN NEURONS; RAT SPINAL-CORD; PROTEIN-COUPLED RECEPTORS; SUBSTANTIA-GELATINOSA NEURONS; MESSENGER-RNA EXPRESSION; PRIMARY AFFERENT NEURONS; PRIMATE STT CELLS; GROUP-II; NEUROPATHIC PAIN; B-RECEPTOR;

D O I：

10.1016/j.brainresrev.2008.12.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamate and gamma-amino butyric acid (GABA) are respectively two major excitatory and inhibitory neurotransmitters of the adult mammalian central nervous system. These neurotransmitters exert their action through two types of receptors: ionotropic and metabotropic receptors. While ionotropic receptors are ligand gated ion channels involved in fast synaptic transmission, metabotropic receptors belong to the superfamily of G-protein coupled receptors (GPCRs) and are responsible for the neuromodulatory effect of glutamate and GABA. Metabotropic glutamate receptors (mGluRs) and metabotropic GABA receptors (GABA-B) are present at different levels of the pain neuraxis where they regulate nociceptive transmission and pain. The present review will focus on the role of these receptors in the modulation of pain perception. (C) 2009 Elsevier B.V. All rights reserved

引用

页码：43 / 56

页数：14

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