Enhanced cell transplantation: preventing apoptosis increases cell survival and ventricular function
被引:40
|
作者:
Nakamura, Yoshinobu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, CanadaUniv Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, Canada
Nakamura, Yoshinobu
[1
]
Yasuda, Tamotsu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, CanadaUniv Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, Canada
Yasuda, Tamotsu
[1
]
Weisel, Richard D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, CanadaUniv Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, Canada
Weisel, Richard D.
[1
]
Li, Ren-Ke
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, CanadaUniv Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, Canada
Li, Ren-Ke
[1
]
机构:
[1] Univ Toronto, Toronto Gen Hosp, Toronto Gen Res Inst, Div Cardiac Surg,Dept Surg, Toronto, ON M5G 1L7, Canada
来源:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
|
2006年
/
291卷
/
02期
Cell transplantation prevents cardiac dysfunction after myocardial infarction. However, because most implanted cells are lost to ischemia and apoptosis, the benefits of cell transplantation on heart function could be improved by increasing cell survival. To examine this possibility, male Lewis rat aortic smooth muscle cells (SMCs; 4 x 10(6)) were pretreated with antiapoptotic Bcl-2 gene transfection or heat shock and then implanted into the infarcted myocardium of anesthetized, syngenic female rats (n = 23 per group). On the first day after transplantation, apoptotic SMCs were quantified by using transferase-mediated dUTP nick-end labeling staining. On days 7 and 28, grafted cell survival was quantified by using real-time PCR, and heart function was assessed with the use of echocardiography and the Langendorff apparatus. SMCs given antiapoptotic pretreatments exhibited improvements in each measure relative to controls. Apoptosis was reduced in Bcl-2-treated cells relative to all other groups (P < 0.05), whereas survival (P < 0.01) was increased. Heat shock also significantly decreased apoptosis and increased survival relative to control groups (P < 0.05 for group effect), although these effects were less pronounced than in the Bcl-2-treated group. Further, scar areas were reduced in both Bcl-2- and heat shock-treated groups relative to controls (P < 0.05), and fractional area change and cardiac function were greater (P < 0.05 for both measures). These results indicate that antiapoptosis pretreatments reduced grafted SMC loss after transplantation and enhanced grafted cell survival and ventricular function, which was directly related (r = 0.72; P = 0.002) to the number of surviving engrafted cells.
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USA
Ramos, Laura
Pena, Geber
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USA
Pena, Geber
Cai, Bolin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USA
Cai, Bolin
Deitch, E. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USA
Deitch, E. A.
Ulloa, Luis
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USAUniv Med & Dent New Jersey, New Jersey Med Sch, Dept Surg,Ctr Immun & Infect, Lab Antiinflammatory Signaling & Surg Immunol, Newark, NJ 07103 USA
Ulloa, Luis
JOURNAL OF IMMUNOLOGY,
2010,
185
(01):
: 709
-
716
机构:
Univ Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, CanadaUniv Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, Canada
Tang, GHL
Fedak, PWM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, CanadaUniv Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, Canada
Fedak, PWM
Yau, TM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, CanadaUniv Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, Canada
Yau, TM
Weisel, RD
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, CanadaUniv Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, Canada
Weisel, RD
Kulik, A
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, CanadaUniv Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, Canada
Kulik, A
Mickle, DAG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, CanadaUniv Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, Canada
Mickle, DAG
Li, RK
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, CanadaUniv Toronto, Toronto Gen Hosp, Dept Surg, Div Cardiovasc Surg, Toronto, ON M5G 2C4, Canada