Quality by Design (QbD) driven Systematic Development of Nano-lipoidal Carrier of Poorly Water Soluble Anti-tubercular agent-Rifabutin.

被引：2

作者：

Patil, Swapnil ^{[1
]}

Gattani, S. G. ^{[1
]}

Nirbhavane, Pradip ^{[2
]}

Katare, O. P. ^{[2
]}

Patil, Kiran ^{[3
]}

机构：

[1] SRTM Univ, Sch Pharm, Nanded 431606, Maharashtra, India

[2] Panjab Univ, UGC Ctr Adv Studies, Univ Inst Pharmaceut Sci, Chandigarh, India

[3] NMIMS, Sch Pharm & Technol Management, Shirpur, Maharashtra, India

来源：

MATERIALS TECHNOLOGY | 2022年 / 37卷 / 08期

关键词：

Nanocarrier; mycobacterium tuberculosis; rifabutin; qbd; box-Behnken Design;

D O I：

10.1080/10667857.2020.1870327

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In the present research work, Rifabutin, drug used for tuberculosis infection, was encapsulated in lipidic nanoparticles with a view to develop a sustained release oral formulation. The nanocarrier loaded rifabutin, prepared by the solvent diffusion evaporation method and evaluated for its physical (nanoparticles size distribution) and chemical (drug content) stability. To optimize the identified independent variables, Box-Behnken Design (BBD) was utilized effectively. The result showed that a size of optimized formulation was found to be 315 +/- 10.96 nm and PDI of 0.310 +/- 0.05; the encapsulation efficiency was found to be (66.3 +/- 3.85). On encapsulation, the nanocarrier showed amorphous pattern of drug studied using X-ray Diffractometric analysis. The release pattern of rifabutin loaded nanocarrier revealed that it represents the sustained release kinetics in comparison to plain drug. Thus, nanotechnology-based formulation may reduce frequency, provide medications more efficaciously, ultimately reducing patient avoidance.

引用

页码：695 / 705

页数：11