Amino acid sequence of the Amur tiger prion protein

被引：3
|
作者：
Wu, Changde
Pang, Wanyong
Zhao, Deming [1 ]
机构：
[1] China Agr Univ, Coll Vet Med, Natl Anim Transmissible Spongiform Encephalopathy, Beijing 100094, Peoples R China
[2] Shenyang Agr Univ, Coll Anim Sci & Vet Med, Liaoning 110161, Peoples R China
[3] Univ Coll Dublin, Fac Vet Med, Dublin 4, Ireland
来源：
VIRUS RESEARCH | 2006年 / 121卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Amur tiger; prion protein gene; polymorphisms; TSE; species barrier;
D O I：
10.1016/j.virusres.2006.05.001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Prion diseases are fatal neurodegenerative disorders in human and animal associated with conformational conversion of a cellular prion protein (PrPC) into the pathologic isoform (PrPSc). Various data indicate that the polymorphisms within the open reading frame (ORF) of PrP are associated with the susceptibility and control the species barrier in prion diseases. In the present study, partial Prnp from 25 Amur tigers (tPrnp) were cloned and screened for polymorphisms. Four single nucleotide polymorphisms (T423C, A501G, C511A, A610G) were found; the C511A and A610G nucleotide substitutions resulted in the amino acid changes Lysine171Glutamine and Alanine204Threoine, respectively. The tPrnp amino acid sequence is similar to house cat (Felis catus AF003087) and sheep, but differs significantly from other two cat Prnp sequences that were previousely deposited in GenBank. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：93 / 96
页数：4
相关论文
共 50 条
  • [1] Amino acid sequence of the Felis catus prion protein
    Lysek, DA
    Nivon, LG
    Wüthrich, K
    GENE, 2004, 341 : 249 - 253
  • [2] Amino acid sequence of the Pekingese dog prion protein gene
    Wu, Changde
    Pang, Wanyong
    Yang, Jianmin
    Zhou, Xiangmei
    Zhao, Deming
    XENOTRANSPLANTATION, 2006, 13 (05) : 471 - 474
  • [3] Prion protein amino acid sequence influences formation of authentic synthetic PrPSc
    Block, Alyssa J.
    York, Taylor C.
    Benedict, Romilly
    Ma, Jiyan
    Bartz, Jason C.
    SCIENTIFIC REPORTS, 2023, 13 (01):
  • [4] Prion protein amino acid sequence influences formation of authentic synthetic PrPSc
    Alyssa J. Block
    Taylor C. York
    Romilly Benedict
    Jiyan Ma
    Jason C. Bartz
    Scientific Reports, 13 (1)
  • [5] Amino acid sequence and prion strain specific effects on the in vitro and in vivo convertibility of ovine/murine and bovine/murine prion protein chimeras
    Kupfer, Leila
    Eiden, Martin
    Buschmann, Anne
    Groschup, Martin H.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2007, 1772 (06): : 704 - 713
  • [6] COMPLETE AMINO ACID SEQUENCE OF A NEUROPHYSIN PROTEIN
    SCHLESIN.DH
    CAPRA, JD
    SCHWARTZ, IL
    WALTER, R
    FEDERATION PROCEEDINGS, 1971, 30 (02) : A363 - &
  • [7] PARTIAL AMINO ACID SEQUENCE OF AN ENCEPHALITOGENIC PROTEIN
    KIBLER, RF
    SHAPIRA, R
    FEDERATION PROCEEDINGS, 1968, 27 (02) : 464 - &
  • [8] AMINO ACID SEQUENCE SELECTION IN PROTEIN SYNTHESIS
    JEHLE, H
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1959, 45 (09) : 1360 - 1371
  • [9] AMINO-ACID POLYMORPHISM IN HUMAN PRION PROTEIN AND AGE AT DEATH IN INHERITED PRION DISEASE
    BAKER, HF
    POULTER, M
    CROW, TJ
    FRITH, CD
    LOFTHOUSE, R
    RIDLEY, RM
    COLLINGE, J
    LANCET, 1991, 337 (8752): : 1286 - 1286
  • [10] A Nine Amino Acid Domain Is Essential for Mutant Prion Protein Toxicity
    Westergard, Laura
    Turnbaugh, Jessie A.
    Harris, David A.
    JOURNAL OF NEUROSCIENCE, 2011, 31 (39): : 14005 - 14017
12345