Copper-Catalyzed Decarboxylative C-P Cross-Coupling of Alkynyl Acids with H-Phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides

被引：97

作者：

Hu, Gaobo

Gao, Yuxing ^{[1
]}

Zhao, Yufen

机构：

[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 17期

关键词：

TERMINAL ALKYNES; DIPHENYLPHOSPHINE OXIDE; VINYLPHOSPHINE OXIDES; INTERMOLECULAR HYDROPHOSPHINATION; STEREOSELECTIVE ADDITION; STEREOSPECIFIC CLEAVAGE; TRANSFER HYDROGENATION; CONJUGATE ADDITION; ARYLBORONIC ACIDS; RADICAL-ADDITION;

D O I：

10.1021/ol502009b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and the stereoselectivity for E-isomers.

引用

页码：4464 / 4467

页数：4

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