APOE Genotype and Cognitive Change in Young, Middle-Aged, and Older Adults Living in the Community

被引:50
作者
Bunce, David [1 ,2 ]
Bielak, Allison A. M. [3 ]
Anstey, Kaarin J. [2 ]
Cherbuin, Nicolas [2 ]
Batterham, Philip J. [4 ]
Easteal, Simon [5 ]
机构
[1] Univ Leeds, Fac Med & Hlth, Inst Psychol Sci, Leeds LS2 9JT, W Yorkshire, England
[2] Australian Natl Univ, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia
[3] Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA
[4] Australian Natl Univ, Ctr Mental Hlth Res, Canberra, ACT, Australia
[5] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2014年 / 69卷 / 04期
基金
澳大利亚国家健康与医学研究理事会; 加拿大健康研究院; 英国医学研究理事会;
关键词
APOE; Cognitive change; Age; Antagonistic pleiotropy; Dementia; APOLIPOPROTEIN-E GENOTYPE; ALZHEIMER-DISEASE; EPSILON-4; ALLELE; DECLINE; MEMORY; ASSOCIATION; HEALTHY; VOLUME;
D O I
10.1093/gerona/glt103
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
We examined whether the apolipoprotein E (APOE) epsilon 4 allele was associated with cognitive benefits in young adulthood and whether it reversed to confer cognitive deficits in later life ("antagonistic pleiotropy") in the absence of dementia-related neuropathology. We also tested whether the epsilon 2 allele was associated with disadvantages in early adulthood but offered protection against cognitive decline in early old age. Eight-year cognitive change was assessed in 2,013 cognitively normal community-dwelling adults aged 20-24, 40-44, or 60-64 years at baseline. Although cognitive decline was associated with age, multilevel models contrasting the epsilon 2 and epsilon 4 alleles provided no evidence that the APOE genotype was related to cognitive change in any of the age groups. The findings suggest that in the absence of clinically salient dementia pathology, APOE epsilon 2 and epsilon 4 alleles do not exhibit antagonistic pleiotropy in relation to cognition between the ages of 20 and 72 years.
引用
收藏
页码:379 / 386
页数:8
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