NMO-IgG antibodies in neuromyelitis optica:: a report of 2 cases

被引：0
|
作者：
Zuliani, L.
de Munain, A. Lopez
Martinez, J. Ruiz
Olascoaga, J.
Graus, F.
Saiz, A.
机构：
[1] Hosp Clin Barcelona, Serv Neurol, Barcelona 08036, Spain
[2] Hosp Donostia, San Sebastian, Spain
[3] Hosp Mendaro Osakidetza, Mendaro, Guipuzcoa, Spain
来源：
NEUROLOGIA | 2006年 / 21卷 / 06期
关键词：
neuromyelitis optica; Devic's syndrome; myelitis; autoantibodies; multiple sclerosis;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction. Neuromyelitis optica is an inflammatory demyelination disease that selectively affects optic nerves and spinal cord. Recently it has been described that the NMO-IgG antibodies, are highly specific for the diagnosis, although they are also present in partial forms of the disease. The antigen responsible for this immune response seems to be aquaporin-4 water channel. Clinical case. We describe the detection in our laboratory of NMO-IgG antibodies in two patients, one of them with a neuromyelitis optica and the other one with a recurrent myelitis and subclinical involvement of the optic nerve. Conclusions. By using dual immunostaining, confocal microscopy showed that the antibodies of both patients colocalized with that of an anti-aquaporin-4 IgG.
引用
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页码：314 / 317
页数：4
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