Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

被引：82

作者：

Dedic, Nina ^{[1
]}

Kuehne, Claudia ^{[1
]}

Jakovcevski, Mira ^{[1
]}

Hartmann, Jakob ^{[1
,2
,3
]}

Genewsky, Andreas J. ^{[1
]}

Gomes, Karina S. ^{[1
,4
]}

Anderzhanova, Elmira ^{[1
]}

Poehlmann, Max L. ^{[1
]}

Chang, Simon ^{[1
]}

Kolarz, Adam ^{[1
]}

Vogl, Annette M. ^{[1
]}

Dine, Julien ^{[1
]}

Metzger, Michael W. ^{[1
]}

Schmid, Bianca ^{[1
]}

Almada, Rafael C. ^{[1
]}

Ressler, Kerry J. ^{[2
,3
]}

Wotjak, Carsten T. ^{[1
]}

Grinevich, Valery ^{[5
]}

Chen, Alon ^{[1
]}

Schmidt, Mathias V. ^{[1
]}

Wurst, Wolfgang ^{[6
,7
,8
]}

Refojo, Damian ^{[1
,9
]}

Deussing, Jan M. ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany

[2] Harvard Med Sch, Dept Psychiat, Belmont, MA USA

[3] McLean Hosp, 115 Mill St, Belmont, MA 02178 USA

[4] Univ Estadual Paulista, Lab Neuropsychopharmacol, Araraquara, Brazil

[5] Heidelberg Univ, Schaller Res Grp Neuropeptides, German Canc Res Ctr, Cent Inst Mental Hlth, Heidelberg, Germany

[6] Helmholtz Zentrum Munchen, Inst Dev Genet, Munich, Germany

[7] Tech Univ Munich, Chair Dev Genet, Munich, Germany

[8] German Ctr Neurodegenerat Dis DZNE, Site Munich, Munich, Germany

[9] Max Planck Gesell, Inst Invest Biomed Buenos Aires IBioBA, CONICET, Partner Inst, Buenos Aires, DF, Argentina

来源：

NATURE NEUROSCIENCE | 2018年 / 21卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

VENTRAL TEGMENTAL AREA; CONDITIONED FEAR; MICE; EXPRESSION; STRESS; FOREBRAIN; MEDIATE; EXTINCTION; RECEPTOR; CIRCUIT;

D O I：

10.1038/s41593-018-0151-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

引用

页码：803 / +

页数：8

共 8 条

[1] Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
Nina Dedic
Claudia Kühne
Mira Jakovcevski
Jakob Hartmann
Andreas J. Genewsky
Karina S. Gomes
Elmira Anderzhanova
Max L. Pöhlmann
Simon Chang
Adam Kolarz
Annette M. Vogl
Julien Dine
Michael W. Metzger
Bianca Schmid
Rafael C. Almada
Kerry J. Ressler
Carsten T. Wotjak
Valery Grinevich
Alon Chen
Mathias V. Schmidt
Wolfgang Wurst
Damian Refojo
Jan M. Deussing
Nature Neuroscience, 2018, 21 : 803 - 807
[2] CRH Acts Anxiolytic by Modulating Dopamine Release through a Subset of GABAergic Long-range Projection Neurons
Dedic, Nina
Kuehne, Claudia
Gomes, Karina
Anderzhanova, Elmira
Hartmann, Jakob
Schmid, Bianca
Kolarz, Adam
Vogl, Annette M.
Wotjak, Carsten T.
Grinevich, Valery
Binder, Elisabeth
Chen, Alon
Schmidt, Mathias V.
Wurst, Wolfgang
Refojo, Damian
Deussing, Jan M.
NEUROPSYCHOPHARMACOLOGY, 2015, 40 : S314 - S314
[3] Long-range GABAergic projection neurons in the cat neocortex
Higo, Shigeyoshi
Udaka, Naoko
Tamamaki, Nobuaki
JOURNAL OF COMPARATIVE NEUROLOGY, 2007, 503 (03) : 421 - 431
[4] Distinct electrophysiological properties of long-range GABAergic and glutamatergic neurons from the lateral amygdala to the auditory cortex of the mouse
Bertero, Alice
Apicella, Alfonso
JOURNAL OF PHYSIOLOGY-LONDON, 2024, 602 (08): : 1733 - 1757
[5] Long-range projections from sparse populations of GABAergic neurons in murine subplate
Boon, Jacqueline
Clarke, Emma
Kessaris, Nicoletta
Goffinet, Andre
Molnar, Zoltan
Hoerder-Suabedissen, Anna
JOURNAL OF COMPARATIVE NEUROLOGY, 2019, 527 (10) : 1610 - 1620
[6] Fear Conditioning Potentiates Synaptic Transmission onto Long-Range Projection Neurons in the Lateral Subdivision of Central Amygdala
Penzo, Mario A.
Robert, Vincent
Li, Bo
JOURNAL OF NEUROSCIENCE, 2014, 34 (07): : 2432 - 2437
[7] NPY+-, but not PV+-GABAergic neurons mediated long-range inhibition from infra- to prelimbic cortex
R Saffari
Z Teng
M Zhang
M Kravchenko
C Hohoff
O Ambrée
W Zhang
Translational Psychiatry, 2016, 6 : e736 - e736
[8] NPY+-, but not PV+-GABAergic neurons mediated long-range inhibition from infra- to prelimbic cortex
Saffari, R.
Teng, Z.
Zhang, M.
Kravchenko, M.
Hohoff, C.
Ambree, O.
Zhang, W.
TRANSLATIONAL PSYCHIATRY, 2016, 6 : e736 - e736

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