Perylene Diimide Oligomer Nanoparticles with Ultrahigh Photothermal Conversion Efficiency for Cancer Theranostics

被引：25
|
作者：
Gong, Qiuyu [1 ]
Xing, Jie [2 ,3 ]
Huang, Yinjuan [1 ]
Wu, Aiguo [2 ,3 ]
Yu, Jing [1 ]
Zhang, Qichun [1 ]
机构：
[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore
[2] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Cixi Inst Biomed Engn, CAS Key Lab Magnet Mat & Devices, Ningbo 315201, Peoples R China
[3] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Addit Mfg Mat Zhejiang Prov, Ningbo 315201, Peoples R China
来源：
ACS APPLIED BIO MATERIALS | 2020年 / 3卷 / 03期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
perylene diimides; photothermal agent; photothermal conversion efficiency; self-assembly; phototheranostics; SEMICONDUCTING POLYMER; NANOSTRUCTURES; NANOMEDICINES; ASSEMBLIES; NANOSHEETS; MOLECULES; THERAPY; OXIDE; SIZE;
D O I：
10.1021/acsabm.9b01187
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Developing one agent that has reasonable stability and ultrahigh photothermal conversion efficiency (PTCE) for near-infrared (NIR) photothermal cancer treatment remains a great challenge, but is highly desirable. In this research, we developed a perylene diimide (PDI)-based oligomer (OPDI) through coupling monomeric PDI derivatives together. OPDI exhibited slightly red-shifted absorption at NIR region compared with monomeric PDI. More importantly, the self-assembled OPDI nanoparticles not only exhibited high stability and preferable biocompatibility, but also possessed an ultrahigh PTCE (up to 79.8%, higher than many other photothermal agents reported before). This OPDI photothermal agent has been demonstrated to exhibit excellent therapeutic effects. Our research provides a guide for the exploitation of photothermal agents with ultrahigh PTCE.
引用
收藏
页码：1607 / 1615
页数：9
相关论文
共 50 条
  • [1] Biodegradable π-Conjugated Oligomer Nanoparticles with High Photothermal Conversion Efficiency for Cancer Theranostics
    Li, Xiaozhen
    Liu, Lu
    Li, Shengliang
    Wan, Yingpeng
    Chen, Jia-Xiong
    Tian, Shuang
    Huang, Zhongming
    Xiao, Ya-Fang
    Cui, Xiao
    Xiang, Chengyan
    Tan, Qinglong
    Zhang, Xiao-Hong
    Guo, Weisheng
    Liang, Xing-Jie
    Lee, Chun-Sing
    ACS NANO, 2019, 13 (11) : 12901 - 12911
  • [2] Ternary Chalcogenide Nanosheets with Ultrahigh Photothermal Conversion Efficiency for Photoacoustic Theranostics
    Zhu, Houjuan
    Lai, Zhuangchai
    Fang, Yuan
    Zhen, Xu
    Tan, Chaoliang
    Qi, Xiaoying
    Ding, Dan
    Chen, Peng
    Zhang, Hua
    Pu, Kanyi
    SMALL, 2017, 13 (16)
  • [3] Carrier-Free Delivery of Ultrasmall π-Conjugated Oligomer Nanoparticles with Photothermal Conversion over 80% for Cancer Theranostics
    Zheng, Rijie
    Zhao, Qi
    Qing, Weixia
    Li, Shengliang
    Liu, Zhonghua
    Li, Qianqian
    Huang, Yongwei
    SMALL, 2022, 18 (04)
  • [4] Polymer nanoparticles with high photothermal conversion efficiency as robust photoacoustic and thermal theranostics
    Guo, Liang
    Liu, Weimin
    Niu, Guangle
    Zhang, Panpan
    Zheng, Xiuli
    Jia, Qingyan
    Zhang, Hongyan
    Ge, Jiechao
    Wang, Pengfei
    JOURNAL OF MATERIALS CHEMISTRY B, 2017, 5 (15) : 2832 - 2839
  • [5] Laser-Synthesized Bismuth Nanoparticles with Controlled Efficiency of Photothermal Conversion for Multimodal Theranostics
    Sozaev, I. V.
    Tikhonowski, G. V.
    Savinov, M. S.
    Shakhov, P. V.
    Skribitskaya, A. V.
    Tselikov, D. I.
    Popov, A. A.
    Zavestovskaya, I. N.
    Klimentov, S. M.
    Kabashin, A. V.
    BULLETIN OF THE LEBEDEV PHYSICS INSTITUTE, 2023, 50 (11) : 498 - 502
  • [6] Laser-Synthesized Bismuth Nanoparticles with Controlled Efficiency of Photothermal Conversion for Multimodal Theranostics
    I. V. Sozaev
    G. V. Tikhonowski
    M. S. Savinov
    P. V. Shakhov
    A. V. Skribitskaya
    D. I. Tselikov
    A. A. Popov
    I. N. Zavestovskaya
    S. M. Klimentov
    A. V. Kabashin
    Bulletin of the Lebedev Physics Institute, 2023, 50 : 498 - 502
  • [7] Chemical doping of unsubstituted perylene diimide to create radical anions with enhanced stability and tunable photothermal conversion efficiency
    Che, Canyan
    Tong, Shaohua
    Jia, Yanhua
    Yang, Jiaji
    He, Xiandong
    Han, Shaobo
    Jiang, Qinglin
    Ma, Yuguang
    FRONTIERS IN CHEMISTRY, 2023, 11
  • [8] Combing NIR-II molecular dye with magnetic nanoparticles for enhanced photothermal theranostics with a 95.6% photothermal conversion efficiency
    Lv, Xiao-Fang
    Ran, Xiao-Yun
    Zhao, Yu
    Zhang, Rui-Rui
    Zhang, Li-Na
    Shi, Jing
    Xu, Ji-Xuan
    Kong, Qing-Quan
    Yu, Xiao-Qi
    Li, Kun
    CHINESE CHEMICAL LETTERS, 2025, 36 (04)
  • [9] Photothermal conversion performance of perylene diimide radical anion salts modified with tunable moieties
    Li, Qizhe
    Hou, Wenlong
    Peng, Fei
    Wang, Hailong
    Zhang, Shuo
    Dong, Danyang
    Wu, Siyu
    Zhang, Haiquan
    JOURNAL OF MATERIALS SCIENCE, 2019, 54 (01) : 217 - 227
  • [10] Photothermal conversion performance of perylene diimide radical anion salts modified with tunable moieties
    Qizhe Li
    Wenlong Hou
    Fei Peng
    Hailong Wang
    Shuo Zhang
    Danyang Dong
    Siyu Wu
    Haiquan Zhang
    Journal of Materials Science, 2019, 54 : 217 - 227
12345