Age specific and attributable risks of familial prostate carcinoma from the family-cancer database

被引:44
|
作者
Hemminki, K [1 ]
Czene, K [1 ]
机构
[1] Karolinska Inst, Novum, Dept Biosci, Huddinge, Sweden
关键词
familial risk; age of onset; brothers; recessive effect; heritable effect;
D O I
10.1002/cncr.10819
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. Familial risks by proband status and age are useful for clinical counseling, and they can be used to calculate population-attributable fractions (PAFs), which show the proportion of disease that could be prevented if the cause could be removed. METHODS. The authors used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 182,104 fathers and 3710 sons with medically verified prostate carcinoma to calculate age specific familial standardized incidence ratios (SIRs) with 95% confidence intervals (95% CI) and familial PAFs for prostate carcinoma in sons ages 0-66 years. RESULTS. The incidence of prostate carcinoma was doubled between the years 1961 and 1998. The familial SIRs for prostate carcinoma were 2.38 (95% CI, 2.182.59) for men with prostate carcinoma in the father only, 3.75 (95% CI, 2.73-4.95) for men with prostate carcinoma in a brother only, and 9.44 (95% CI, 5.76-14.03) for men with prostate carcinoma in both a father and a brother. The corresponding familial PAFs were 8.86%, 1.78%, and 0.99%, respectively, yielding a total PAF of 11.63%. Age specific risks were shown for the same proband histories. The SIR was 8.05 for prostate carcinoma before age 55 if a brother had been diagnosed before that age. If, in addition, a father was diagnosed at any age, then the SIR was 33.09. CONCLUSIONS. The authors recommend that having a brother who is diagnosed with prostate carcinoma before age 55 years or having a brother and father who are diagnosed at any age are indications to screen for prostate carcinoma. The familial PAF of prostate carcinoma among a population of sons ages 0-66 years was 11.63%. (C) 2002 American Cancer Society.
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页码:1346 / 1353
页数:8
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