Spectrophotometric estimation of celecoxib in bulk and its pharmaceutical formulation

被引：0
|
作者：
Sahu, S. K. [1 ]
Azam, Md. Afzal [2 ]
Dash, Dillip Ku. [1 ]
Banarjee, M. [1 ]
机构：
[1] Utkal Univ, Univ Dept Pharmaceut Sci, Bhubaneswar 751005, Orissa, India
[2] JSS Coll Pharm, Dept Pharmaceut Chem, Ootacamund 643001, Tamil Nadu, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2009年 / 86卷 / 03期
关键词：
Spectrophotometry; celecoxib; sodium hydroxide; methanol; correlation coefficient;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new simple, precise, sensitive, highly specific and economical ultraviolet spectrophotometric method for the determination of celecoxib in bulk and its pharmaceutical formulation (dispersible tablets and capsules) has been developed. The absorbance maxima of celecoxib in a mixture of methanol and 0.01 N sodium hydroxide (1 : 1 v/v) were determined at 253.1 nm. Beer's law is obeyed over concentration range of 8-22 mu g/ml with correlation coefficient r > 0.999. The results have been validated statistically and by recovery studies.
引用
收藏
页码：308 / 311
页数：4
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