New bioactive marine steroids from the Okinawan soft coral Clavularia viridis

被引：16
|
作者：
Watanabe, K [1 ]
Iwashima, M [1 ]
Iguchi, K [1 ]
机构：
[1] TOKYO UNIV PHARM & LIFE SCI,SCH LIFE SCI,BIOORGAN CHEM LAB,HACHIOJI,TOKYO 19203,JAPAN
来源：
STEROIDS | 1996年 / 61卷 / 07期
关键词：
soft coral; Clavularia viridis; structure; X-ray crystallographic analysis; cell growth inhibition;
D O I：
10.1016/0039-128X(96)00077-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eight new marine steroids were isolated from the Okinawan soft coral Clavularia viridis Quoy and Gaimard. Their structures were determined based on spectroscopic analysis, chemical conversion, and X-ray crystallographic analysis. Steroids 5 and 6 showed growth inhibition activity toward HeLa S3 cells and human diploid cells in vitro.
引用
收藏
页码：439 / 446
页数：8
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