Hemoglobin-Based Red Blood Cell Substitutes and Nitric Oxide

被引：32
|
作者：
Yu, Binglan [1 ]
Bloch, Kenneth D. [1 ]
Zapol, Warren M. [1 ]
机构：
[1] Harvard Univ, Dept Anesthesia & Crit Care, Sch Med, Massachusetts Gen Hosp,Anesthesia Ctr Crit Care R, Boston, MA 02114 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2009年 / 19卷 / 03期
关键词：
INHALED NO; INFARCTION; HEMOLYSIS; INJURY; MODEL;
D O I：
10.1016/j.tcm.2009.06.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hemoglobin-based oxygen carriers (HBOCs) have been studied for decades as red blood cell substitutes. Profound vasoconstrictor effects have limited the clinical utility of HBOCs and are attributable to avid scavenging of nitric oxide (NO). Inhaling NO can charge the body's stores of NO metabolites without producing hypotension and can prevent systemic hypertension induced when HBOCs are subsequently infused. Concurrent breathing of low NO doses can prevent pulmonary vasoconstriction after HBOC infusion without augmenting plasma methemoglobinemia. (Trends Cardiovasc Med 2009; 19:103-107) (C) 2009, Elsevier Inc.
引用
收藏
页码：103 / 107
页数：5
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