Infrequent Wnt inhibitory factor-1 (Wif-1) methylation in chronic lymphocytic leukemia

被引：20
|
作者：
Chim, C. S.
Fung, T. K.
Wong, K. F.
Lau, J. S.
Liang, R.
机构：
[1] Univ Hong Kong, Dept Med, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
[2] Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
[3] Queen Elizabeth Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
来源：
LEUKEMIA RESEARCH | 2006年 / 30卷 / 09期
关键词：
Wif-1; methylation; CLL; Chinese;
D O I：
10.1016/j.leukres.2005.12.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Wnt pathway has been shown recently, to be activated in patients with chronic lymphocytic leukemia (CLL). This is the first study to examine the role of Wnt inhibitory factor-1 (Wif-1) methylation in the pathogenesis of haematolymphoid malignancies. Wif-1, a putative tumor suppressor, is a soluble negative regulator of the Wnt pathway activated in CLL. We studied the role of methylation of Wif-1 in 43 Chinese patients with CLL. At diagnosis, Wif-1 methylation was detected in 5/43 (11.6%) CLL marrow samples. Wif-1 methylation occurred more frequently in patients with advanced age (p = 0.059) but there was no correlation between Wif-1 methylation and sex, lymphocyte count and Rai stage at diagnosis. In conclusion, Wif-1 is infrequently methylated in CLL. Other factors leading to activation of the Wnt pathway warrant further study. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1135 / 1139
页数：5
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