Electrospun scaffolds for tissue engineering of vascular grafts

被引:573
|
作者
Hasan, Anwarul [1 ,2 ]
Memic, Adnan [3 ]
Annabi, Nasim [1 ,2 ]
Hossain, Monowar [4 ]
Paul, Arghya [1 ,2 ]
Dokmeci, Mehmet R. [1 ,2 ]
Dehghani, Fariba [5 ]
Khademhosseini, Ali [1 ,2 ,6 ,7 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Biomed Engn,Dept Med, Cambridge, MA 02139 USA
[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[3] King Abdulaziz Univ, Ctr Nanotechnol, Jeddah 21589, Saudi Arabia
[4] Univ Adelaide, Lyell McEwin Hosp, Dept Med, Adelaide, SA 5112, Australia
[5] Univ Sydney, Sch Chem & Biomol Engn, Sydney, NSW 2006, Australia
[6] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
[7] Tohoku Univ, WPI AIMR, Sendai, Miyagi 9808577, Japan
基金
加拿大自然科学与工程研究理事会; 美国国家科学基金会; 美国国家卫生研究院; 英国医学研究理事会;
关键词
Electrospinning; Tubular scaffolds; Vascular grafts; Tissue engineering; Mechanical properties; SURFACE MODIFICATION; BLOOD-VESSEL; STEM-CELLS; PORE-SIZE; EXTRACELLULAR-MATRIX; POLYMER NANOFIBERS; FIBER DIAMETER; ADHESION; ACID); PROLIFERATION;
D O I
10.1016/j.actbio.2013.08.022
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
There is a growing demand for off-the-shelf tissue engineered vascular grafts (TEVGs) for the replacement or bypass of damaged arteries in various cardiovascular diseases. Scaffolds from the decellularized tissue skeletons to biopolymers and biodegradable synthetic polymers have been used for fabricating TEVGs. However, several issues have not yet been resolved, which include the inability to mimic the mechanical properties of native tissues, and the ability for long-term patency and growth required for in vivo function. Electrospinning is a popular technique for the production of scaffolds that has the potential to address these issues. However, its application to human TEVGs has not yet been achieved. This review provides an overview of tubular scaffolds that have been prepared by electrospinning with potential for TEVG applications. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:11 / 25
页数:15
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