Mechanisms of action of low doses of polyethylene glycol in the treatment of functional constipation

Different doses of polyethylene glycol have different effects on intestinal function. In normal volunteers, low doses increase stool weighs without modifying oro-anal transit time. In constipated patients, low doses decrease stool consistency increase stool frequency, and facilitate stool evacuation without modifing stool weight and colonic transit time. Low doses of polyethylene glycol may be efficient in the treatment of functional constipation by effecting dilution water in the faeces and thus, reducing stool consistency.