Aging of the hematopoietic stem cells niche

被引：26
|
作者：
Nakamura-Ishizu, Ayako [1 ]
Suda, Toshio [1 ]
机构：
[1] Keio Univ, Dept Cell Differentiat, Sakaguchi Lab, Shinjuku Ku, Tokyo 1608582, Japan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2014年 / 100卷 / 04期
基金：
日本学术振兴会;
关键词：
Aging; Hematopoietic stem cells; Niche; Bone marrow; BONE-MARROW NICHE; AGE-RELATED-CHANGES; PROGENITOR CELLS; CRE-RECOMBINASE; IN-VIVO; DROSOPHILA TESTIS; TRANSGENIC MOUSE; ENDOTHELIAL-CELLS; MULTIPLE-MYELOMA; ELDERLY-PATIENTS;
D O I：
10.1007/s12185-014-1641-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.
引用
收藏
页码：317 / 325
页数：9
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