Palladium-Catalysed Synthesis of α-(Trifluoromethyl)styrenes by Means of Directed C-H Bond Functionalization

被引：19

作者：

Zhao, Qun ^{[2
]}

Besset, Tatiana ^{[2
]}

Poisson, Thomas ^{[2
]}

Bouillon, Jean-Philippe ^{[1
,2
]}

Pannecoucke, Xavier ^{[2
]}

机构：

[1] Normandie Univ, COBRA, UMR 6014, F-76821 Mont St Aignan, France

[2] Univ Rouen, INSA Rouen, CNRS, F-76821 Mont St Aignan, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 01期

关键词：

Synthetic methods; Fluorine; C-H activation; Palladium; Homogeneous catalysis; ALPHA-TRIFLUOROMETHYLSTYRENE DERIVATIVES; MEDICINAL CHEMISTRY; ORTHO-ARYLATION; ARYL HALIDES; FLUORINE; ALKENES; ARENES; 2-BROMO-3,3,3-TRIFLUOROPROPENE; TRIFLUOROMETHYLTHIOLATION; DIFLUOROACETYLATION;

D O I：

10.1002/ejoc.201501217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the first introduction of 2-bromo-3,3,3-trifluoropropene (BTP) by directed C-H bond functionalization. The developed method gives straightforward access to -(trifluoromethyl)styrene derivatives without prior prefunctionalization of the substrates. This palladium-catalysed transformation was applied to a broad range of substrates, and the corresponding trifluoromethylated products were obtained in good yields. This approach represents an alternative pathway to the classical method previously used to access such molecules.

引用

页码：76 / 82

页数：7

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