Sequence-specific DNA recognition by polyamides

被引：292

作者：

Dervan, PB ^{[1
]}

Bürli, RW ^{[1
]}

机构：

[1] CALTECH, Dept Chem, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1367-5931(99)00027-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA sequences. Some of these polyamides have been shown to inhibit specific gene expression in mammalian cell culture.

引用

页码：688 / 693

页数：6

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