Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding

被引:36
|
作者
Utsugi, Chizuru [1 ,2 ]
Miyazono, Sadaharu [2 ]
Osada, Kazumi [3 ]
Sasajima, Hitoshi [2 ]
Noguchi, Tomohiro [2 ]
Matsuda, Mitsuyoshi [1 ]
Kashiwayanagi, Makoto [2 ]
机构
[1] Asahikawa Med Univ, Dept Oral & Maxillofacial Surg, Asahikawa, Hokkaido, Japan
[2] Asahikawa Med Univ, Dept Sensory Physiol, Asahikawa, Hokkaido, Japan
[3] Hlth Sci Univ Hokkaido, Sch Dent, Dept Oral Biol, Tohbetu, Japan
来源
PLOS ONE | 2014年 / 9卷 / 05期
基金
日本学术振兴会;
关键词
NEURAL STEM-CELLS; AGED SAMP8 MICE; ADULT NEUROGENESIS; PEDUNCULOPONTINE NUCLEUS; HIPPOCAMPAL NEUROGENESIS; PARIETAL CORTEX; SPATIAL MEMORY; DENTATE GYRUS; TOOTH LOSS; BULB;
D O I
10.1371/journal.pone.0097309
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal sensory trigeminal nucleus (Pr5), which receives intraoral touch information via the trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB.
引用
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页数:9
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