Palladium-Catalyzed C( sp3)- H Activation: A Facile Method for the Synthesis of 3,4-Dihydroquinolinone Derivatives**

被引：87

作者：

Yan, Jia-Xuan ^{[1
,2
]}

Li, Hu ^{[1
,2
]}

Liu, Xiang-Wei ^{[1
,2
]}

Shi, Jiang-Ling ^{[1
,2
]}

Wang, Xin ^{[1
,2
]}

Shi, Zhang-Jie ^{[1
,2
,3
]}

机构：

[1] Peking Univ, PKU Green Chem Ctr, Beijing Natl Lab Mol Sci BNLMS, Beijing 100871, Peoples R China

[2] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Chem, Beijing 100871, Peoples R China

[3] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 19期

关键词：

CH activation; dihydroquinolinones; palladacycles; palladium; synthetic methods; INTRAMOLECULAR ALKANE ARYLATION; PROTON-ABSTRACTION MECHANISM; BOND ACTIVATION; UNACTIVATED C(SP(3))-H; EFFICIENT SYNTHESIS; DIRECTING GROUP; FUNCTIONALIZATION; LIGAND; ACID; (HETERO)ARENES;

D O I：

10.1002/anie.201402562

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3,4-Dihydroquinolinones were synthesized by the palladium-catalyzed, oxidative-addition-initiated activation and arylation of inert C(sp(3))H bonds. Pd(OAc)(2) and P(o-tol)(3) were used as the catalyst and ligand, respectively, to improve the efficiency of the reaction. A further advantage of this reaction is that it could be performed in air. A relatively rare seven-membered palladacycle was proposed as a key intermediate of the catalytic cycle.

引用

页码：4945 / 4949

页数：5

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