Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

被引：3

作者：

Yee, JoAnn L. ^{[1
]}

Prongay, Kamm ^{[2
]}

Miles, Brodie ^{[2
]}

Smedley, Jeremy ^{[2
]}

Hansen, Scott G. ^{[2
]}

Axthelm, Michael K. ^{[2
]}

Ardeshir, Amir ^{[1
]}

Van Rompay, Koen K. A. ^{[1
]}

Timmel, Gregory ^{[2
]}

Roberts, Jeffrey A. ^{[1
]}

机构：

[1] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA

[2] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Beaverton, OR USA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 2019年 / 48卷 / 04期

关键词：

cell-mediated immune response (CMI); interferon-gamma release assay (IGRA); purified protein derivative-tuberculin (PPD); DIAGNOSIS; OUTBREAK;

D O I：

10.1111/jmp.12420

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

引用

页码：260 / 263

页数：4

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