Drug repurposing approaches to fight Dengue virus infection and related diseases

被引：44

作者：

Botta, Lorenzo ^{[1
]}

Rivara, Mirko ^{[2
]}

Zuliani, Valentina ^{[2
]}

Radi, Marco ^{[2
]}

机构：

[1] Univ Tuscia, Biol & Ecol Dept DEB, I-01100 Viterbo, Italy

[2] Univ Parma, Dept Food & Drug, Viale Sci 27-A, I-43124 Parma, Italy

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷

关键词：

Dengue virus; Neglected Diseases; Drug repurposing; Review; POTENT INHIBITOR; MYCOPHENOLIC-ACID; HELICASE ACTIVITY; REPLICATION; PROTEIN; CELGOSIVIR; IVERMECTIN; NELFINAVIR; DISCOVERY; FEVER;

D O I：

10.2741/4630

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropod-born viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention. Herein, we will describe the most recent drug repurposing approaches to fight DENV infection and their implications in antiviral drug-discovery.

引用

页码：997 / 1019

页数：23

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