Outwardly rectifying K+ channels display clustering in guinea pig retinal Muller cells

被引：2
|
作者：
Pannicke, T [1 ]
Reichenbach, A [1 ]
Reichelt, W [1 ]
机构：
[1] Univ Leipzig, Paul Flechsig Inst Brain Res, Dept Neurophysiol, D-04109 Leipzig, Germany
来源：
NEUROSCIENCE LETTERS | 1999年 / 276卷 / 01期
关键词：
voltage-dependent K+ channels; cell-attached patch-clamp; guinea pig; retinal glia cells;
D O I：
10.1016/S0304-3940(99)00793-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The cell-attached configuration of the patch-clamp technique was used to characterize the outward currents in acutely isolated Muller cells from the guinea pig retina. Sixty-five of 353 patches displayed macroscopic, outwardly rectifying currents due to depolarizing voltage steps. Single channel transitions were found in only two patches. The remaining patches did not reveal any voltage-dependent currents. Tail current analysis revealed a reversal potential close to the resting membrane potential. The currents disappeared if internal K+ was replaced by Cs+ in inside-out patches. From these results we conclude that guinea pig Muller cells possess voltage-dependent K+ channels that are distributed in clusters. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：13 / 16
页数：4
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