The present Work aimed to determine the period prior to interference and the total prevent ion period to interference of weeds in sugarcane (ratoon) cultivar SP 80-3280. The experiment was carried out on a Dark Red Oxisol. The treatments consisted of increasing periods of presence or absence of weeds: 0, 0 15, 0-34, 0-59. 0-90, 0-124, 0 157, 0-269 days (sugarcane harvest). The most common weeds found in the experimental area were Panicum maximum, Acanthospermum hispidum and Altemanthera tenella. The results obtained. admitting 2% and 5% reduction in sugarcane productivity, showed that the period prior to interference ice tolerated by the culture was 9 and 18 clays after ratoon sprout (DAS) and the total prevention period to interference was 200 and 137 DAS, respectively, resulting in a critical period of prevention to interference from 9 days at 200 DAS of 296 reduction, to 18 days at 137 DAS, of 5% reduction.