A Point-of-Care Prothrombin Time Test on a Microfluidic Disk Analyzer Using Alternate Spinning

被引：9

作者：

Lin, Chia-Hui ^{[1
]}

Lin, Kun-Wei ^{[1
]}

Yen, Daniel ^{[1
]}

Shih, Chih-Hsin ^{[1
]}

Lu, Chien-Hsing ^{[2
,3
,4
,5
]}

Wang, Jiunn-Min ^{[6
]}

Lin, Chi-Yu ^{[6
]}

机构：

[1] Feng Chia Univ, Dept Chem Engn, Taichung 40724, Taiwan

[2] Taichung Vet Gen Hosp, Dept Obstet, Taichung 40705, Taiwan

[3] Taichung Vet Gen Hosp, Dept Gynecol, Taichung 40705, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Dept Obstet, Taipei 112, Taiwan

[5] Natl Yang Ming Univ, Sch Med, Dept Gynecol, Taipei 112, Taiwan

[6] Taichung Vet Gen Hosp, Dept Pathol & Lab Med, Taichung 40705, Taiwan

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2015年 / 15卷 / 02期

关键词：

Prothrombin Time Test; Microfluidic Disk Analyzer; Plasma Separation; Alternate Spinning; Centrifugal Microfluidics; WHOLE-BLOOD; DEVICE; WARFARIN; FLOW; ANTICOAGULATION; PREVENTION; INTENSITY; THERAPY; PLASMA; CHIP;

D O I：

10.1166/jnn.2015.9533

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, we conducted a fully integrated point-of-care prothrombin time test on a microfluidic disk analyzer. The microfluidic functions integrated on the disk were capable of separating whole blood, decanting plasma, and mixing it with reagents in sequence under alternate spinning. The assay protocol was completed by alternate spinning without using microvalves or surface modification. Clinical sample tests on prothrombin time measurement were conducted by both the microfluidic disk analyzer and the reference instrument used in medical centers. The test results showed a good correlation and agreement between the two instruments.

引用

页码：1401 / 1407

页数：7

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